Publications
Santos CM, Cizubu BK, Okonkwo DA, Chen CY, Maske N, Snyder NA, Simoes V, Washington EJ, Silva GM. Redox control of the deubiquitinating enzyme Ubp2 regulates translation during stress. J Biol Chem. 2024 Oct 7:107870. doi: 10.1016/j.jbc.2024.107870. Epub ahead of print. PMID: 39384040.
Washington EJ, Zhou Y, Hsu AL, Petrovich M, Tenor JL, Toffaletti DL, Guan Z, Perfect JR, Borgnia MJ, Bartesaghi A, Brennan RG. Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: A target for antifungals. Proc Natl Acad Sci U S A. 2024 Aug 6;121(32):e2314087121. doi: 10.1073/pnas.2314087121. Epub 2024 Jul 31. PMID: 39083421; PMCID: PMC11317593.
Gaggioli, MR, Jones AG, Panagi I, Washington EJ, Loney RE, Muench JH, Brennan RG, Thurston TLM, and Ko DC. A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory target gene expression. bioRxiv [Preprint]. 2024 February 14. https://doi.org/10.1101/2024.02.14.580367.
Washington EJ, Zhou Y, Hsu AL, Petrovich M, Borgnia MJ, Bartesaghi A, Brennan RG. Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: a target for novel antifungals. bioRxiv [Preprint]. 2023 Mar 14:2023.03.14.530545. doi: 10.1101/2023.03.14.530545. PMID: 36993618; PMCID: PMC10054996.
Schott BH, Wang L, Zhu X, Harding AT, Ko ER, Bourgeois JS, Washington EJ, Burke TW, Anderson J, Bergstrom E, Gardener Z, Paterson S, Brennan RG, Chiu C, McClain MT, Woods CW, Gregory SG, Heaton NS, Ko DC. Single-cell genome-wide association reveals that a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus. Cell Genom. 2022 Nov 9;2(11):100207. doi: 10.1016/j.xgen.2022.100207. PMID: 36465279; PMCID: PMC9718543.
Gibbs KD, Washington EJ, Jaslow SL, Bourgeois JS, Foster MW, Guo R, Brennan RG, Ko DC. The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3. Cell Host Microbe. 2020 Jan 8;27(1):129-139.e4. doi: 10.1016/j.chom.2019.11.012. Epub 2019 Dec 31. PMID: 31901521; PMCID: PMC6952535.
Miao Y, Tenor JL, Toffaletti DL, Washington EJ, Liu J, Shadrick WR, Schumacher MA, Lee RE, Perfect JR, Brennan RG. Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7148-53. doi: 10.1073/pnas.1601774113. Epub 2016 Jun 15. PMID: 27307435; PMCID: PMC4932955.
Washington EJ, Mukhtar MS, Finkel OM, Wan L, Banfield MJ, Kieber JJ, Dangl JL. Pseudomonas syringae type III effector HopAF1 suppresses plant immunity by targeting methionine recycling to block ethylene induction. Proc Natl Acad Sci USA. 2016 Jun 21;113(25):E3577-86. doi: 10.1073/pnas.1606322113. Epub 2016 Jun 6. PMID: 27274076; PMCID: PMC4922156.
Washington EJ, Banfield MJ, Dangl JL. What a difference a Dalton makes: bacterial virulence factors modulate eukaryotic host cell signaling systems via deamidation. Microbiol Mol Biol Rev. 2013 Sep;77(3):527-39. doi: 10.1128/MMBR.00013-13. PMID: 24006474; PMCID: PMC3811613.
Akimoto-Tomiyama C, Furutani A, Tsuge S, Washington EJ, Nishizawa Y, Minami E, Ochiai H. XopR, a type III effector secreted by Xanthomonas oryzae pv. oryzae, suppresses microbe-associated molecular pattern-triggered immunity in Arabidopsis thaliana. Mol Plant Microbe Interact. 2012 Apr;25(4):505-14. doi:10.1094/MPMI-06-11-0167. PMID: 22204644.